Ultram (tramadol hydrochloride) is a centrally acting analgesic. The chemical name for tramadol hydrochloride is (?)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl cyclohexanol hydrochloride.
The molecular weight of this drug is 299.8.It is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The water/n-octanol partition coefficient is 1.35 at pH 7. Ultram tablets contain 50 mg of hydrochloride and are white in color. Inactive ingredients in the tablet are corn starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and wax.
Buy tramadol - precautions
If you intend to take this medication make sure first of all you consult a doctor and inform him of any history of liver disease, kidney disease or alcohol or drug dependence. If you have any of the conditions listed about then you may have to take the medicine in different dosages than normal, or may request special monitoring during the time you are taking it. If you are pregnant make sure you consult a doctor first before you buy tramadol, as it is not sure if it will be harmful in any way for an unborn baby, or if it will transfer into breast milk, given that the medicine is in the FDA pregnancy category C. Also consult your doctor if you are breast-feeding. Although there are not any significant side effects caused by this medicine, the probability of those over 75 years of age to experience them is increased. For this category , 75 years and over, the maximum daily dose to be taken is 300 mg. Children under 16 years of age are not allowed to buy Tramadol and use it as this practice is not approved by the FDA.
The directions on the label are to be followed exactly. If there are any misunderstandings do not hesitate to contact your doctor or pharmacist. Because it tends to be habit –forming, therefore instead of taking larger doses, administer it either for a longer time or more often.
Tramadol clinical pharmacology
Pharmacodynamics Ultram is a centrally acting synthetic analgesic compound that is not derived from natural sources nor is it chemically related to opiates. Although its mode of action is not completely understood from animal tests, at least two complementary mechanisms appear applicable; binding to ?-opioid receptors and inhibition of reuptake of norepinephrine and serotonin. This product opioid activity derives from low affinity binding of the parent compound to ?-opioid receptors and higher affinity binding of the M1 metabolite. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in ?-opioid binding. The contribution to human analgesia of tramadol relative to M1 is unknown.
Tramadol-induced antinociception is only partially antagonized by the opiate naloxone in several animal tests. In addition, it has been shown to inhibit reuptake of norepinephrine and serotonin in vitro, as have some other opioid analgesics. These latter mechanisms may contribute independently to the overall analgesic profile of this medicine. Onset of analgesia in humans is evident within one hour after administration and reaches a peak in approximately two to three hours. Peak plasma concentrations are reached about two hours after administration of the drug, which correlates closely with the time to peak pain relief.
Apart from analgesia, administration of this drug may produce a constellation of symptoms (including dizziness, somnolence, nausea, constipation, sweating and pruritus) similar to that of an opioid. However, drug tramadol causes significantly less respiratory depression than morphine. In contrast to morphine, it has not been shown to cause histamine release. At therapeutic doses, it has no effect on heart rate, left-ventricular function or cardiac index. Orthostatic changes in blood pressure have been observed.
Side effects may occur
Some side affects may occur although they are not very common. Migraines and speech disorder in the central nervous system, and gastrointestical bleeding, hepatitis, stomatitis and liver failure in the gastrointestinal system are the most often noted events that may occur. If any symptoms such as drowsiness, headaches, dizziness, blurred vision, vomiting, upset stomach and diarrhea become severe or do not fully disappear, report them do your doctor. Report the following symptoms immediately: redness, swelling, fast heartbeat, itching of the face, difficulty breathing, numbness or tingling of the hands and feet, changes in urination and seizures.
